‘The Thyroid Detective: Finding the Real Culprit — A Root-Cause Framework for Common Thyroid Presentations’

You don’t need to specialise in thyroid health for this to matter to your practice. Thyroid function touches almost everything you see in clinic, fatigue, weight changes, mood, fertility, digestion, skin and hair, sleep, and cycle irregularities. Whatever your focus, there’s a strong chance an undiagnosed or under-addressed thyroid picture is quietly sitting underneath cases you’re already working on.

And too often, it stays hidden. The patient has textbook symptoms. Standard bloodwork comes back “normal.” The GP says there’s nothing wrong. The patient knows something is and the trail goes cold there.

This session is about knowing where to look next. Sonia O’Donnell and Izzy Seadon unpack a cellular framework for understanding thyroid dysfunction, the mechanism behind how chronic stress, mitochondrial strain, infection, gut and liver function, hormonal shifts, and toxin load can each quietly disrupt thyroid hormone conversion at the tissue level, often invisible to standard testing. This is the piece that turns “I don’t know why my patient still feels awful” into a clear, testable, actionable hypothesis.

If you’ve ever suspected a case had a thyroid piece you couldn’t quite pin down, this is the session that shows you how to find it.

In this session, you will learn:

• Why thyroid dysfunction can hide behind normal-looking standard bloodwork, and the cellular mechanism that explains why
• How to read a fuller thyroid panel, including functional ratios that catch what standard testing misses
• The six most common root causes behind thyroid dysfunction in clinical practice — relevant whether you specialise in hormones, gut health, fatigue, fertility, or general practice
• A practical four-phase framework for building a protocol that’s sequenced to actually work
• How this plays out in real case presentations, so you can apply it in clinic the next day

‘Recurrent Vaginal Symptoms and Dysbiosis’
Understanding BV, Aerobic Vaginitis, Thrush and the Role of Lactobacilli in Vaginal Health

Abnormal vaginal discharge, odour, irritation and discomfort are among the most common reasons women seek healthcare advice. However, bacterial vaginosis (BV), aerobic vaginitis (AV) and vulvovaginal candidiasis (thrush) are distinct conditions with different underlying microbial drivers, often making accurate identification and long-term management challenging.

This webinar will explore the vaginal microbiome and the important role of Lactobacillus spp. in maintaining the vaginal environment. Attendees will gain a practical understanding of how changes in the vaginal microbiome can contribute to dysbiosis and recurrent symptoms, while exploring how BV, AV and thrush differ in their microbial drivers, presentation and aetiology.

The session will review current evidence surrounding microbiome restoration strategies, including the emerging role of targeted probiotic supplementation. Clinical evidence for specific, well-studied probiotic strains will be discussed including Lactobacillus rhamnosus GR-1® and Limosilactobacillus reuteri RC-14®, alongside practical considerations for supporting vaginal health, evidence relating to recurrence, and the use of microbiome-focused approaches alongside conventional management.

By the end of the session, delegates will have a greater understanding of the relationship between the vaginal microbiome and recurrent vaginal symptoms, enabling them to make more informed, evidence-based recommendations in clinical practice.

Learning Objectives

By the end of this webinar, delegates will be able to:

• Differentiate the key clinical and microbial characteristics of bacterial vaginosis, aerobic vaginitis and vulvovaginal candidiasis.
• Understand the role of Lactobacillus spp. and vaginal microbial ecology in maintaining vaginal health.
• Recognise how different patterns of vaginal dysbiosis may contribute to recurrent vaginal symptoms.
• Evaluate current evidence for targeted probiotic interventions in vaginal health.
• Apply microbiome-focused strategies alongside conventional approaches to support women experiencing recurrent vaginal symptoms.

‘Beyond “Detox”: Using Pharmacogenetics to Understand Drug Activation, Clearance and Biotransformation’

Beyond “Detox”: Using Pharmacogenetics to Understand Drug Activation, Clearance and Biotransformation
Detoxification is frequently discussed as a generalised process of “removing toxins”, yet clinically it represents a coordinated system of Phase I biotransformation, antioxidant protection and Phase II conjugation that also determines how many medications are activated, metabolised and eliminated.

This presentation uses an anonymised female case study to demonstrate how genetic data can provide additional context for individual variation in drug response.

The profile identifies potentially reduced CYP2D6 activity, with implications for reduced activation of prodrugs such as codeine and tramadol, while medications dependent on CYP2D6 for clearance may instead achieve higher exposure.

A CYP2C19 intermediate metaboliser profile provides a contrasting example, where reduced enzyme activity may decrease activation of clopidogrel while slowing clearance of medications including proton pump inhibitors, selected antidepressants and diazepam – particularly important with a family history of depression.

The case also explores how Phase I metabolism must be considered alongside downstream metabolic capacity.

Variants affecting SULT1A1 sulphation, GSTM1 glutathione conjugation and UGT1A6 glucuronidation illustrate how reactive intermediates and drug metabolites ultimately require effective antioxidant buffering and Phase II elimination.
Rather than using genotype to dictate prescribing, the presentation proposes a pathway based approach integrating pharmacogenetics with medication history, drug-drug and drug-nutrient interactions, clinical response and appropriate monitoring.

The aim is to demonstrate how genetic information can help explain unexpected efficacy or adverse effects of prescription medication while supporting safer, more individualised medication use.

‘Mould & the Cell: Building Resilience from the Inside Out’

Mould exposure is often approached through avoidance and detoxification, but understanding the cellular response to environmental stressors adds an important layer to the clinical picture. In this webinar, Dr. John Kim, Pharm.D., FAARFM, will explore mould through a cellular health lens, connecting environmental exposures with mitochondrial function, cell membrane health, redox balance, nervous system regulation, gut health, and endogenous detoxification pathways. He will discuss strategies designed to support normal cellular function and resilience, with an emphasis on building physiological capacity and supporting the cellular foundations that help the body adapt, regulate, and restore balance.